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Patrudu, T. B.
- A New Analytical method Validation and Quantification of Entacapone and its Related Substance in bulk Drug Product by HPLC
Abstract Views :380 |
PDF Views:1
Authors
Affiliations
1 Department of Chemistry, Krishna University, Machilipatnam, A.P., IN
2 Department of Chemistry, GITAM University, Hyderabad Campus, Telangana, IN
1 Department of Chemistry, Krishna University, Machilipatnam, A.P., IN
2 Department of Chemistry, GITAM University, Hyderabad Campus, Telangana, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 1 (2017), Pagination: 1-5Abstract
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of entacapone and its related impurities are (N, N diethyl cyano acetamide), (3,4 Dihydroxy 5-Nitro benzaldehyde) and (2-Z)-2-Cyano-3-(3,4-Dihydroxy-5-nitrophenyl)N,N-diethyl-2- propenamide. The chromatographic separations were achieved on (250×4.6 mm), 5.0 μm make: Phenomenex Luna column employing Acetonitrile: HPLC Water in the ratio of 50:50 (v/v) as mobile phase with isocratic at flow rate 0.9 mL/min was chosen. Three impurities were eluted within 15 minutes. The column temperature was maintained at 30°C and a detector wavelength of 210 nm was employed. The method was successfully validated by establishing System Suitability, Specificity, Linearity, Accuracy, limit of detection and Limit of quantification.Keywords
HPLC, Method Validation, Related Impurities, Entacapone, LOQ, LOD.- A New High-Performance Liquid Chromatographic Method for Identification and Quantification of Fosinopril Sodium and its Related Impurities in Bulk Drug Product
Abstract Views :375 |
PDF Views:5
Authors
Affiliations
1 Department of Organic Chemistry, Gayathri PG College, Vizianagaram, Andhra Pradesh, IN
2 Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, IN
3 Department of Chemistry, Gitam University, Hyderabad Campus, Telangana, IN
1 Department of Organic Chemistry, Gayathri PG College, Vizianagaram, Andhra Pradesh, IN
2 Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, IN
3 Department of Chemistry, Gitam University, Hyderabad Campus, Telangana, IN